ABSTRACT
An assortment of clinical and laboratory abnormalities may occur as paraneoplastic syndromes in lymphomas. Rheumatological and dermatological manifestations such as paraneoplastic arthritis and pyoderma gangrenosum must be underscored. We report a 28 years old woman who developed pyoderma gangrenosum and two years later presented with arthritis of knees and ankles associated with panniculitis interpreted as erythema induratum that was pathologically confirmed. She developed a reactivation of pyoderma gangrenosum, that was refractory to treatment. Complementary studies showed a pulmonary nodule and a right paravertebral mass with involvement of the psoas muscle. Biopsies of both masses and a new pathological skin study demonstrated a large B-cell non-Hodgkin's lymphoma.
Subject(s)
Humans , Female , Adult , Paraneoplastic Syndromes/complications , Arthritis/etiology , Lymphoma, Non-Hodgkin/complications , Panniculitis/etiology , Pyoderma Gangrenosum/etiology , Paraneoplastic Syndromes/diagnosis , Paraneoplastic Syndromes/drug therapy , Arthritis/diagnosis , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/drug therapy , Panniculitis/diagnosis , Pyoderma Gangrenosum/drug therapyABSTRACT
Paraneoplastic syndromes are common in mesotheliomas but there is no report from India. Two cases of pleural mesothelioma with paraneoplastic haematologic syndromes, one with neutrophilic leukemoid reaction and the other with thrombocytosis, are presented in this report.
Subject(s)
Adult , Cisplatin/therapeutic use , Cytokines/therapeutic use , Humans , India , Magnetic Resonance Imaging , Male , Paraneoplastic Syndromes/blood , Paraneoplastic Syndromes/diagnosis , Paraneoplastic Syndromes/drug therapy , Solitary Fibrous Tumor, Pleural/diagnosis , Solitary Fibrous Tumor, Pleural/drug therapy , Thrombocytosis/diagnosis , Thrombocytosis/drug therapyABSTRACT
Os autores fazem uma revisão bibliográfica sobre carcinoma de células renais, sua epidemiologia manifestações clínicas, síndromes paraneoplásicas associadas, estadiamento e terapêutica.